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By the 1990s though, cyclists and other endurance athletes had discovered that they could train longer and harder if they took the drug regularly. Not surprisingly, taking EPO comes with significant risk. Studies have shown that it increases the risk of events such as stroke, heart attack and pulmonary edema. One theory suggests that the drug thickens the blood to the point where it produces fatal clots, which steroids are best for building muscle. Such complications may have contributed to the deaths of at least 20 cyclists by 2000, increasing the urgency to develop a reliable test to detect EPO [source: Zorpette].
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